Microwave-Assisted Synthesis of Phenothiazine and Quinoline Derivatives

نویسندگان

  • Luiza Găină
  • Castelia Cristea
  • Claudia Moldovan
  • Dan Porumb
  • Emanoil Surducan
  • Călin Deleanu
  • Abdalah Mahamoud
  • Jacques Barbe
  • Ioan A. Silberg
چکیده

Application of a dynamic microwave power system in the chemical synthesis of some phenothiazine and quinoline derivatives is described. Heterocyclic ring formation, aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensation reactions were performed on solid support, or under solvent free reaction conditions. The microwave-assisted Duff formylation of phenothiazine was achieved. Comparison of microwave-assisted synthesis with the conventional synthetic methods demonstrates advantages related to shorter reaction times and in some cases better reaction yields.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2007